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Studies have shown that regular exercise not only effectively prevents and treats various liver diseases [4-9], but also reduces the risk of liver cancer and improves the quality of life in patients with chronic liver diseases through multiple mechanisms, including improving lipid profiles, regulatory myokines, maintaining muscle mass, and increasing insulin sensitivity [10]

Dohi Y., Ikura T., Hoshikawa Y., Katoh Y., Ota K., Nakanome A., Muto A., Omura S., Ohta T., Ito A., Yoshida M., Noda T., Igarashi K., Nat

The gastrointestinal epithelium represents an important interface between the host and the external environment, serving both as a surface for absorption as a defence against ingested pathogens

This prevents the hydroxylation of HIF-1, thereby blocking its recognition and subsequent degradation by the VHL-mediated proteasomal system [96, 97]