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Once released by ferroptotic cells, these extracellular DAMPs bind to the receptor advanced glycosylation end-product specific receptor (AGER) on macrophages and trigger either proinflammatory cytokine production in a nuclear factor-B (NF-B)-dependent manner or macrophage polarization-associated tumor progression ( Figure1 )

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Tumilaar SG, Hardianto A, Dohi H, Kurnia D

Cadaverine has also been implicated in transient receptor potential cation channel subfamily V member 1 (TRPV1) receptor activation in neurons, leading to itch [242]