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Indeed, NRF2-silenced cells showed downregulation of the GSH-synthesising enzymes GCLC and GSR (Supplementary Figure S6B), demonstrating a direct link between NRF2 activity and GSH synthesis
[DOI] [Google Scholar] 47.Tanner E.E.L., Curreri A.M., Balkaran J.P.R., Selig-Wober N.C., Yang A.B., Kendig C., Fluhr M.P., Kim N., Mitragotri S
L., Yolken R
For the corresponding disulfide of strep-MBP-GRXC2, the midpoint redox potential was also found to range between 230 and 240 mV
