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Moreover, in a study, an innovative strategy was employed to enhance the therapeutic index of interleukin-12 (IL-12) by targeting its delivery to tumors ( 2.4 Modulating cytokines in the tumor microenvironment using peptides Cytokines play pivotal roles in orchestrating immune responses and driving the progression of PCa (Mao et al., 2021)

Repeated injections in the same location can cause localized inflammation, lipohypertrophy (thickened fat deposits), or increased nerve sensitivity that amplifies the burning sensation