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1 Introduction Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interaction, characterized by recurrent abdominal pain associated with changes in stool frequency or form ( Figure 1 summarizes this multifactorial model: genetic susceptibility establishes host predisposition

Despite the great number of antineoplastic drugs available in the market, only a few of them have been tested on preclinical and clinical studies of CICI, emphasizing the lack of clinical evaluation of cognition-related side effects

Day-to-day life produces substances called free radicals that circulate in the body