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Results showed TMAO inhibited autophagy and activated NLRP3 inflammasome, which were reversed by ATG16L1 or NLRP3 knockdown, indicating a mechanistic link in IBD pathogenesis

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In a retrospective study, 25 pediatric patients refractory to conventional CVS therapies were treated with aprepitant at the beginning of the prodromal phase (Table 7), resulting in a decrease in vomiting duration and frequency in 76% of the patients (136)

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