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Those who take trazodone for an extended period may experience: Memory problems Weight gain Muscle weakness Heart rhythm issues Low blood pressure Another potential long-term side effect of trazodone is a condition called serotonin syndrome

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11 Additionally, two letters included observations for failure to obtain informed consent from participants in accordance with 21 CFR 50 12 and failure to retain documentation for two years pursuant to 21 CFR 312

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