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The examination of much larger cohorts in longitudinal studies that also integrate clinical phenotypes and diet are thus needed for a more comprehensive understanding of these populations

doi: 10.3389/fimmu.2023.1153915 44 HillAAReid BolusWHastyAH

Elevated IGF-1 levels raise concerns about potential proliferative effects on existing malignancies, making growth hormone therapy problematic for individuals with cancer history or elevated cancer risk

While the theoretical rationale is sound, no clinical trial has tested this specific combination, and the safety profile of triple-pathway activation through separate compounds is unknown