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Over the past decade, preclinical and clinical studies have demonstrated their efficacy in treating immune-inflammatory disorders, respiratory diseases, musculoskeletal defects, cardiocerebral vascular pathologies, neurodegenerative conditions, metabolic disorders, and neoplastic diseases

97 found that isocaloric protein restriction down to 12E% over 3 months was not able to reproduce the beneficial metabolic changes induced by CR in male C57BL/6 mice, in particular the decrease in IGF-1 concentrations

Clin Transplant 21:767772 Van Schravendijk CF, Kiekens R, Pipeleers DG (1992) Pancreatic beta cell heterogeneity in glucose-induced insulin secretion

Because of such features, nanozymes, as a new generation of antibacterial agents, have been widely used in the fields of antibacterial applications 22