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In a double-blind randomized controlled trial of 46 bipolar disorder patients, N-acetylcysteine (2000 mg/d) treatment for 6 months did not result in any significant differences in cognitive measures including digit span, word learning, trail making, and verbal fluency when compared with the placebo group (15)

In mouse models, the loss of thioredoxin reductase 2 (Txnrd2) results in an endothelial phenotype that promotes thrombosis, as Txnrd2-deficient mice develop widespread microthrombi in arteries, arterioles, and capillaries, suggesting a systemic tendency toward thrombosis [46]

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Gallbladder issues increase during rapid weight loss regardless of method