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3.1.2 Clinical translation: trials and challenges Translation to human trials has progressed through several phases, with early-phase studies primarily assessing safety and feasibility
Retinoids are metabolized to retinoic acid via enzymatic reactions, which bind to RARs and RXRs and activate the transcription factor intestine-specific homeobox (ISX), which suppresses transcription of BCO1 and SCARB1
Skip alcohol and go easy on caffeine on treatment day
