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Data collection was performed on a Titan Krios (Thermo Fischer Scientific) electron microscope operated at 300 kV equipped with Gatan Falcon 4 detector

Additionally, treatment of DIO mice with the NNMT inhibitor resulted in a substantial ~35% decrease ( P 30% decrease in adipocyte size ( P 40% decrease in adipocyte volume (data not shown) compared to control DIO mice

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Brushing with vitamin-infused toothpaste allows the nutrients to get absorbed via sublingual and transbuccal routes (transbuccal means through the inside of your cheek)