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Comparative analysis with other emerging modalities, including monoclonal antibodies, GLP-1 analogs, gene editing tools, and microbiome modulators, suggests that integrated strategies combining nanotechnology with molecular inhibition may offer the most effective path forward

The sequential peaking of Pdfgra -positive cells at 4 weeks, Enpp6 -positive cells at 5 weeks, and strong Mbp -positive cells at 5+1 weeks, and these cells together with the Plp -, weak Mbp-, and Mog -positive cells that have decreased sharply at early time and gradually recovered from 3 weeks to 5 or 5+1 weeks, respectively, and then remained at a higher level than intact control as long as to 5+4 weeks, provided a clear overall dynamic profile of OL lineage cells throughout de-and remyelination period of the standardized CPZ model (Fig.8)

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