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Safety and Effectiveness of Longer-Term Phentermine Use: Clinical Outcomes from an Electronic Health Record Cohort

While tirzepatide does not undergo significant renal clearance, limited safety data exist in severe kidney disease

Additionally, trials of oligonucleotide therapeutics and some small-molecule NNMT inhibitors in vitro and in preclinical animal models have validated NNMT as a promising therapeutic target to prevent or treat obesity and related T2D, but currently, clinical trials have not yet been reported

Huynh FK, Hershberger KA, Hirschey MD
