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Side effects Temporary nausea/vomiting, abdominal pain, diarrhea, and body odor may occur

For instance, TMAO triggers NLRP3 inflammasome formation and activates NF-B signaling, Caspase-1, the PERK/Akt/mTOR pathway, and IL-1, leading to increased renal fibrosis ( in vitro study found that TMAO down-regulates Gadd45a expression by mediating the nuclear translocation of Y-box binding protein-1, thus inhibiting cell cycle progression ( In summary, TMAO contributes to CKD progression, indicating that targeting TMAO could be a promising treatment strategy

In other words, patients can perform daily activities such as wearing clothes or using the toilet, but their overall planning or cognitive function and exercise performance might suffer [318]