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Patients using semaglutide-containing medications may experience side effects, and these can vary based on individual factors and medical history

Implications Resistance mechanisms that undermine the immunomodulatory effects of CD38targeting therapies can be tumor intrinsic, such as the downregulation of CD38 surface expression and expression of complement inhibitor proteins, and immune microenvironmentrelated, such as changes to the natural killer (NK) cell numbers and function in the bone marrow niche

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