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Medical conditions like anaemia, hypothyroidism and polycystic ovarian syndrome can also increase pigmentation

[DOI] [PMC free article] [PubMed] [Google Scholar] 78.Tan DX, Manchester LC, Reiter RJ, Qi WB, Karbownik M, Calvo JR

(2021), most patients see measurable improvements within 36 months of consistent use, with continued improvement up to 12 months

Acetaminophen hepatotoxicity: an update
