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Additionally, hypoxic cancer-associated fibroblasts induced blood vessel abnormalities by altering the secretion of various pro- and anti-angiogenic factors leading to changes in endothelial cell function and promoting angiogenesis (Figure 1 illustrates angiogenic activity in the tumor microenvironment
therefore a thorough evaluation is usually recommended
ScienceDirect,
You should always take methylene blue under the supervision of a doctor
