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Furthermore, research indicates that higher CA125 concentrations may be associated with poorer outcomes in individuals diagnosed with EC (123)

doi: 10.1196/annals.1297.070

1 Introduction Phytochemicals, a diverse group of bioactive compounds found in plants, are the subject of renewed interest in biomedical research for their chemopreventive and chemotherapeutic properties (George et al., 2021

Ferroptosis-related genes that are transcriptionally regulated by Nrf2 have been reported, these include genes for GSH regulation (synthesis, cysteine supply via SLC7A11, GSH reductase, GPX4), NADPH regeneration which is critical for GPX4 activity [glucose-6-phosphate dehydrogenase (G6PD), phosphogluconate dehydrogenase, malic enzyme], and iron regulation (including iron export and storage, heme synthesis, and catabolism) (Kerins and Ooi, 2018)