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French RCT The EFFET Trial (Renard et al., 2020) A 12-week placebo-controlled pilot trial with 19 children found that low-dose leucovorin (5 mg twice daily) significantly improved core autism symptoms [6]

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Hemopexin accumulates in kidneys and worsens acute kidney injury by causing hemoglobin deposition and exacerbation of iron toxicity in proximal tubules
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