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In the kidneys with TLS, Gpx4 expression was modestly decreased, while Acsl4 expression was increased compared with controls, consistent with ferroptosis-associated changes (Supplemental Figure 13)
"Diagnosis of ME/CFS | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)"
Nakazato T, Sagawa M, Yamato K, Xian M, Yamamoto T, Suematsu M, Ikeda Y, Kizaki M

A prudent path is to assess for folate sensitivity in the history and to quantify methylation statustypically with whole-blood histamine and a methylation pathway panel (SAM, SAH, homocysteine)before attempting high-dose folate
