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In research, GH secretagogues are usually grouped into two major categories: GHRH analogs, which activate the growth hormonereleasing hormone receptor Ghrelin/GHSR agonists, which activate the growth hormone secretagogue receptor Both pathways can increase GH-axis activity, but they do so through different upstream signals

Elevations in transaminases were seen more frequently in patients with osteoarthritis than in those with rheumatoid arthritis

Within the locus coeruleus (a brainstem nucleus in the dorsal pontine tegmentum) the end product of the pathway is norepinephrine

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