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They also contribute to brain homeostasis [308], mediate protective neuroinflammation, and promote neuronal plasticity at the site of neuronal injury [129]
M.LiY.FomenkoD

When NADPH binds to the oxidized SjTGR, it transfers the electrons sequentially to FAD, to the nearby C154/C159 redox couple, then to C596/U597 redox active couple on the C-terminal segment of the neighboring subunit, and ultimately to either various downstream oxidized substrates such as SjTrx1 and SjTRP14 or back to the redox-active C28-C31 motif in the Grx domain of the neighboring monomer to reduce GSSG (Fig 7)

Most peptides are destroyed in the digestive system, which is why injectable forms dominate the market
