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Normal skin typically tolerates daily application from the start, though alternate-day introduction remains a sensible precaution

Adding NMN or NR is low-risk and often noticeably effective within 48 weeks

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9 Furthermore, in participants receiving antihypertensive medication at baseline, CagriSema led to a greater proportion of participants able to decrease or stop treatment with antihypertensive medications compared with placebo and other monotherapies