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The TM1 stalk (135-138) of CTR in the Cagri CT-like conformation also undergoes rearrangement relative to the bypass conformation, in which the phenyl of F137 1.28 packs against F15 Cagri , H18 Cagri and S19 Cagri (Fig
[DOI] [PMC free article] [PubMed] [Google Scholar] 57.McGill M.R., Staggs V.S., Sharpe M.R., Lee W.M., Jaeschke H., Acute Liver Failure Study Group Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome

Remarkably, this specific sequence is considered to be essential and fully responsible for biological activities of the compound [30]