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Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4

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Further, limited expression of multiple peroxidases is essential to maintain the LR growth by assisting in the maintenance of ROS build-up and by regulating cell wall processes at the primordial stage in an auxin-free manner

These mice, however, did not show increased stroke area with middle cerebral artery occlusion, suggesting that overexpression of neuroglobin might be protective through mechanisms not related to oxygen buffering