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IGF-1 also promotes VEGF expression by activating multiple signaling pathways, such as PI3K/Akt and MAPK/ERK, thereby stimulating angiogenesis essential for follicular growth [32]

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How Long to Take L-Carnitine Oral carnitine has been shown to increase the levels of muscle carnitine, but some studies have shown that meaningful increases can take up to six months to occur

Trends Food Sci Technol 70:18
