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Subsequent investigations demonstrated that FSP1, regulated by Nrf2, significantly inhibited lung cancer cell growth and sensitised Keap1 -deficient cells to ferroptosis by knockdown or inhibition of FSP1 expression in Keap1 post-mutant lung cancer [46, 78]
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Taking 5-amino-1mq with food introduces exogenous nicotinamide from protein metabolism, which competes for NNMT binding sites and reduces the peptides effective concentration at the target enzyme
