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While MIMS-iron upregulates transcripts to genes codifying to C1QA, C1QB, C1QC, and CFD, AIMS upregulates to activators of the C1Q complex, C1Q receptors, and C3
E2 is considered as the major product of this process which plays an important role before menopause, while the significance of E1 grows after menopause [7]
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