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5 This is significant because the proteins encoded by these genes facilitate the autophagic clearance of dysfunctional mitochondria, a quality control mechanism called mitophagy

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Moreover, recent studies suggest that the induction of cellular senescence, rather than the promotion of apoptosis through radiotherapy or chemotherapy, might be the main mechanism for impairing the self-renewal capacity of cancer cells, particularly in the context of solid tumors [55]

Supports integrated longevity pathway investigation: Aging is influenced by interconnected processes including telomere shortening, oxidative stress, and circadian disruption