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Some protocols use 0.6% acetic acid instead of BAC water for improved stability

Activation of certain conventional, novel, and atypical PKC isoforms has been shown to occur through oxidation of the kinases cysteine-rich zinc finger region, which causes release of zinc and subsequent instigation of kinase activity independently of DAG or calcium [196]

In that scenario, succinate supplement could be beneficial, reestablishing directionality of the TCA cycle, supporting the electron transport chain and forcing the T cell into a more tolerant state

Because B12 is water-soluble, the NIH Office of Dietary Supplements notes that no tolerable upper intake level has been established excess B12 is excreted by the body rather than accumulating to toxic levels