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More serious consequences of deficiency include

For example, referral to psychiatrists may be helpful since ME/CFS seems to coexist with anxiety disorders, symptoms of ME/CFS overlap with Major Depressive Disorder (MDD), and patients with severe ME/CFS may also be at risk of developing secondary MDD (36, 532)

Your body does not make vitamin B12 on its own, so you have to get it from outside sources

Role of B Vitamins in Mental Health B vitamins, including B12, B9, and B1, are crucial for proper brain function