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SP-D promotes atherogenesis by 1) Lowering HDL levels, 2) Enhancing OSCAR-mediated macrophage TNF production, 3) Inducing circulating monocytes and macrophage proliferation, 4) Enhancing foam cell accumulation and plaque formation and 5) Decreasing atherosclerotic plaque smooth muscle cell coverage (97, 99101)
doi: 10.2174/2212798410666180221105503

PDAC cells tend to decompose and utilize extracellular proteins for amino acids, while NSCLC cells extract nitrogen by breaking down circulating BCAAs
