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Binzel, T.J
however, the focus of this article is on pain management in patients with hypermobile EDS (hEDS) and those with hypermobility spectrum disorder (HSD), collectively referred to as hypermobility disorder (HD)
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Here we assign the agonist-dependent activation trigger at TM6 to the ligand-binding region of H264 6.54 F261 6.51 directly adjacent to the helix-kink at the CWxP 6.50 motif, which is involved in the known toggle-switch activation mechanism with the resulting TM6 movement typical for class A GPCRs (Fig
