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Translational studies using exosomes showed a relationship between the epigenetic modulation of glutamatergic function and a brain metabolic dysfunction known as insulin resistance (IR) as showed by an increase and sex-specific phosphorylation in the expression of IRS1, a key marker of the insulin signaling cascade, in discrete exosomes enriched for the neural cell adhesion molecule L1 (L1CAM), a protein highly expressed in the brain [52, 70,71,72]

L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: A randomized and controlled clinical trial

Threshold cycle numbers were transformed using the cycle threshold and relative value method described by the manufacturer and were expressed relative to glyceraldehyde-3-phosphate dehydrogenase, which was used as a housekeeping gene

Carnitine, valproate, and toxicity