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Description
Hepatic cancer cell line-based models Although PHHs have become the preferred cell source for liver toxicity assessments, the use of immortalized liver cancer cell lines as alternatives to address the limitations of PHHs has been proposed

However, this process results in the generation of O 2 - and H 2 O 2 (Kumar et al., 2018) (Figure 1)

Insufficient in-depth analysis of the disulfidptosis mechanism has led many existing studies to focus on superficial phenomena, with inadequate systematic research on its regulatory networks, upstream/downstream signaling pathways, and specific intracellular targets ( in vivo detection methods limits its clinical application and efficacy monitoring

Pinardi E
