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10.1152/ajpgi.00113.2021 61

Relative to benchmarks, these novel mRNA designs have exhibited 2.3 - 2.9 fold increase in protein expression and a 128-fold increase in antibody response for vaccines, demonstrating the importance of UTR engineering and codon optimization [ et al ., has developed the algorithm known as iCodon which is a machine learning model trained with mRNA stability from zebrafish, Xenopus embryos, human cell lines, and mouse embryonic stem cells, to predict mRNA stability based on codon composition

Macrophages: versatile players in renal inflammation and fibrosis