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Description
Since the liver is the major site of IGF-1 production, when steatosis develops lowering insulin sensitivity, the severity of steatosis at different stages of insulin resistance and metabolic syndrome seems to be correlated with worsened circulating IGF-1 levels [234]
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Lancet 390 (10113), 26272642
It received GRAS (Generally Recognized as Safe) status for use as a food ingredient, which is a separate regulatory category
