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In addition, irreversible inhibitors of PAD4 (e.g., F- and Cl-amidine) covalently bind to Cys645 at the PAD4 active site (212), significantly reducing histone citrullination and inhibiting the formation of NETs (213)

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Rayyan software (Ouzzani et al., 2016) was employed for reference management, including the identification and removal of duplicate entries