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It is important to mention that rodent models show resistance to F toxicity of 5tenfold compared to humans, pointing out that 50 mg/L is equivalent to 10 mg/L or 500 M in humans (concentration used in this study), which has been described as endemic in several regions in Mexico and worldwide [10, 13, 15,16,17,18]
SIRT3 is a key mitochondrial deacetylase, and activates cyclophilin D and the mitochondrial antioxidant SOD2 [128]
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