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Acute Supplementation Protocol for Moderate-Intensity Exercise Performance (5079% O 2 max ) Along with the intake of CHO, doses of 3 g of l-C 3 h before exercise at 65% O 2 max on a cycle ergometer and doses of 2 g taken 2 h before a marathon race and 20 km after start did not find significant improvements in the power achieved during 40 min on the cycle ergometer or in total time in a marathon [20,24]

Discussion This study adopted a comprehensive approach combining nano-drug delivery, genetic modification, and single-cell sequencing to systematically investigate mitochondrial quality control dysfunction and the activation of cardiomyocyte pyroptosis in DOX-induced myocardial injury