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In vitro and in vivo Down syndrome models revealed that supplementation of mice with low molecular weight antioxidants such as -tocopherol reduced the level of oxidative stress, attenuated degeneration of cholinergic neurons, and improved working memory (Lockrow et al

A recent study mentioned an interesting use of Epitalon

Clinical trials have demonstrated a mean weight loss of approximately 15% of initial body weight over 68 weeks when combined with lifestyle changes

However, the researchers cautioned that no long-term safety studies have been done with T4 treatment in the eye for more than a month [6]
