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The mechanism by which topiramate affects the body is by markedly increasing the activity of inhibitory neurotransmitters
Meeker-OConnell, L
E., AbdelShaheed C., Underwood M., et al., Efficacy, Safety, and Tolerability of Antidepressants for Pain in Adults: Overview of Systematic Reviews, Bmj 380 (2023): e072415
When this happens alongside a steep decline in NAD+, cells lose both the engine that powers repair and the shield that blocks damage
