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Description
There are various functional autoantibodies in patients with systemic sclerosis secreted by dysregulated B cells that target endothelial cells, intercellular adhesion molecule 1 (ICAM-1), endothelin type A receptor (ETAR), angiotensin II type I receptor (AT1R) and platelet-derived growth factor receptor (PDGFR)

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Adultes : Carence en vitamine B12 sans complication clinique (par exemple anmie pernicieuse et malabsorption) Carence en vitamine B12 avec complications cliniques (par exemple : neuropathie secondaire dans la carence en vitamine B12) Prvention de la carence en vitamine B12 (par exemple : aprs une gastrectomie ou un syndrome de malabsorption) Utilisation en cas d'insuffisance rnale svre Utilisation en cas d'insuffisance hpatique

References: Cook, A.K
