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The absence of IGF-1 elevation carries important safety implications
Activation of CB1R by THC disrupts the balance between excitatory and inhibitory neurotransmission, particularly affecting GABAergic and glutamatergic systems (Castelli et al., 2023a
While the astrocyte-neuron lactate shuttle (ANLS) hypothesis (Pellerin and Magistretti, 1994), which emphasizes lactate transfer and its subsequent oxidative metabolism, has gained substantial experimental support, alternative viewpoints exist
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