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Description
MitoROS generation can activate the NLR family pyrin domain containing 3 (NLRP3) inflammasome, inducing pyroptosis, 137 or trigger GSDME-dependent pyroptosis via the ROS/JNK/Bax pathway
Importantly, sulforaphane-mediated NRF2 activation can also be neuroprotective in models of induced epilepsy when administered post-seizure
The choice depends on the patients health, how severe the deficiency is, and the doctors opinion
This section will highlight several key ferroptosis targets, as illustrated in Fig
