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Description
The fact that wild-type ATXN3 binds to components of the transcriptional machinery in cells, as well as the transcriptional changes reported in animal models of SCA3 in the presymptomatic phase, favors the theory of a general transcriptional dysregulation as an initiating factor of SCA3 [117,118,119]
Additional studies investigated its effects on bone fracture healing and muscle crush injury models, with researchers examining markers of tissue regeneration and vascularization
Alternatively, a recent study has shown that patients with neurosarcoidosis frequently have macular edema, even in the absence of ocular symptoms (43)
Methods 9 , 676682 (2012)
