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doi:10.1056/NEJMoa042976 89

Associations between genetic variants of NADPH oxidase-related genes and blood pressure responses to dietary sodium intervention: The GenSalt Study

The pharmacological chaperone isofagomine increases the activity of the Gaucher disease L444P mutant form of beta-glucosidase
Its pathophysiology involves several mechanisms: Persistent hyperglycemia, along with toxic substrates, affects multiple cells in the peripheral nervous system, including Schwann cells, axons, and neurons in the dorsal root ganglion, as well as vascular cells