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Traeger A

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5A, as concentrations of RSL3 higher than 1 M further induced cell death), and under these conditions, IRE1 deficiency would increase cystine uptake and GSH level through SLC7A11 and GCLC upregulation, mitigating the effects of GPX4 inhibition by RSL3

[DOI] [PubMed] [Google Scholar] 152.Rihacek M, Kosaristanova L, Fialova T, Kuthanova M, Eichmeier A, Hakalova E, et al