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Description
36 Fernndez-MartnezJ.Ramrez-CasasY.YangY.Aranda-MartnezP.Martnez-RuizL.EscamesG.et al (2023)

(39407841) overall epidemiology Pyroglutamic acidosis is rare, with only ~130 reported cases in the literature

Key points Abdominal pain in chronic constipation (FC/IBS-C) stems from fecal/gas distension, gut dysbiosis (e.g., histamineproducing bacteria), serotonin imbalances (linked to IBS-C pain), and neural dysfunction (central/peripheral sensitization)
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